Strack Lab, Carver College of Medicine, University of Iowa Iowa City, Iowa
Aims of the Fellowship
Mitochondrial fragmentation (fission) is responsible for neuronal death in stroke and other neurodegenerative diseases. Thus, blocking mitochondrial fission can protect neurons from a variety of threats. Targeting the fission enzyme, dynamin-related protein 1 (Drp1), is problematic because it is an essential and ubiquitous enzyme in the body. Instead, we hypothesize that inhibiting a neuron-specific activator of Drp1 may provide therapeutic benefit in multiple neurological disorders characterized by mitochondrial dysfunction, including stroke and other neurodegenerative diseases.